C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/20 (2006.01) A61K 31/439 (2006.01) C07D 498/20 (2006.01)
Patent
CA 2587508
Spiro compounds according to formula (I): wherein the radical R1 represents NR7R9, R2, R3, R7, R8, R"8 are as herein defined, and wherein ring A represents a 5 or 6 membered heteroring substituted once or twice with a keto substituent. These compounds and their pharmaceutical acceptable salts are used in combinations or in pharmaceutical compositions and are useful in the modulation of CCR5 chemokine receptor activity.
La présente invention a pour objet des composés spiro de formule (I) : où le radical R1 représente NR7R9, R2, R3, R7, R8, R"8 sont tels que définis dans la présente invention, et où le cycle A représente un hétérocycle à 5 ou 6 chaînons incluant un ou deux substituant(s) cétone. Ces composés, ainsi que leurs sels de qualité pharmaceutique, peuvent être employés sous forme combinée ou dans des préparations pharmaceutiques et servent à moduler l'activité du récepteur de chimiokine CCR5.
Blais Charles
Bubenik Monica
Chan Chun Kong Laval
Courchesne Marc
Moinet Christophe
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Virochem Pharma Inc.
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