Novel spla2 inhibitors

C - Chemistry – Metallurgy – 01 – B

Patent

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C01B 21/16 (2006.01) C07D 209/14 (2006.01) C07D 209/22 (2006.01)

Patent

CA 2356159

A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.

La présente invention concerne une classe de nouveaux indoles, et concerne également l'utilisation de tels composés pour inhiber la libération d'acides gras, laquelle libération résulte d'une médiation sPLA¿2?. Cette inhibition vise à remédier des états liés à des maladies inflammatoires, tels que le choc septique.

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