C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) A61K 31/70 (2006.01) A61K 38/43 (2006.01) A61K 39/085 (2006.01) C07K 14/31 (2006.01) C07K 16/40 (2006.01) C12N 9/00 (2006.01) C12N 15/31 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2214866
spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.
Polypeptides spo-rel et ADN (ARN) codant ces spo-rel; méthode pour obtenir ces polypeptides grâce à des techniques recombinantes. Méthodes utilisant ces spo-rel pour le traitement des infections, notamment des infections bactériennes. Antagonistes contre ces spo-rel et leur emploi comme agents thérapeutiques pour traiter les infections, notamment les infections bactériennes. Épreuves de diagnostic pour la détection des maladies associées à la présence de séquences d'acides nucléiques et de polypeptides spo-rel chez un hôte. Épreuves de diagnostic pour déceler les polynucléotides codant la famille du gène relA/spoT, et les polypeptides chez un hôte.
Burnham Martin Karl Russel
Gentry Daniel Robert
Hodgson John Edward
Lawlor Elizabeth Jane
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
Smithkline Beecham P.l.c.
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