Novel stable liquid paracetamol compositions, and method for...

A - Human Necessities – 61 – K

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A61K 31/16 (2006.01) A61K 9/08 (2006.01) A61K 31/167 (2006.01) A61K 31/19 (2006.01) A61K 31/485 (2006.01) A61K 31/56 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/18 (2006.01) A61K 47/20 (2006.01) A61K 47/26 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2233924

Novel stable paracetamol compositions for use in therapeutic chemistry and specifically galenic pharmacy are disclosed. The compositions contain a solution of paracetamol in an aqueous solvent combined with a buffer having a pH of 4 to 8, and a free radical capturing agent. A water-insoluble inert gas is carefully bubbled through the aqueous solvent to remove oxygen from the medium. Said compositions may also be combined with a centrally or peripherally acting analgesic agent, and are provided as injectable compositions for relieving pain.

L'invention concerne le domaine de la chimie thérapeutique et plus spécialement celui de la pharmacie galénique. Elle a plus particulièrement pour objet de nouvelles formulations à base de paracétamol, stables, renfermant du paracétamol en solution dans un solvant aqueux additionné d'un tampon pH 4 à 8, d'un agent capteur de radicaux libres, en prenant soin de faire barboter dans le solvant aqueux un gaz inerte, insoluble dans l'eau pour chasser l'oxygène du milieu. Les préparations selon l'invention peuvent être additionnées, en outre, d'un agent antalgique à action centrale ou à action périphérique. Utilisation sous forme de préparations injectables pour le traitement de la douleur.

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