Novel stat3 pathway inhibitors and cancer stem cell inhibitors

Details Novel stat3 pathway inhibitors and cancer stem cell inhibitors Novel stat3 pathway inhibitors and cancer stem cell inhibitors

C - Chemistry, Metallurgy

07

D

C07D 307/92 (2006.01) A61K 31/343 (2006.01)

Patent

CA 2736532

The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds.

La présente invention concerne une nouvelle classe naphto de composés utilisés comme inhibiteurs de la voie Stat3 et comme inhibiteurs de cellules souches cancéreuses, des procédés d'utilisation de ces composés pour traiter le cancer, des procédés d'utilisation de ces composés pour traiter des troubles chez un mammifère associés à une activité aberrante de la voie Stat3 et, des compositions pharmaceutiques contenant ces composés.

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