Novel steroid esters useful against skin disorders

C - Chemistry – Metallurgy – 07 – J

Patent

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C07J 1/00 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2231781

Novel steriod esters useful for regulating skin atrophy, and skin maladies, as well as compositions containing the esters and methods for their use are described. A preferred steroid ester is DHEA salicylate. Such types of skin atrophy to be treated include the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells. Such skin maladies include but are not limited to dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritis, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.

L'invention concerne des esters stéroïdes nouveaux qui permettent de réguler l'atrophie de la peau et les maladies cutanées, ainsi que des compositions à base desdits esters et certains procédés relatifs à leur utilisation. L'ester stéroïde préféré est un salicylate de déshydro-épiandrostérone (DHEA). Parmi les types d'atrophie de la peau à traiter figurent l'amincissement/ou la détérioration générale du derme qui se caractérise souvent par une diminution du collagène et/ou de l'élastine et aussi par une diminution du nombre, de la taille et du potentiel de duplication des fibroblastes. Parmi les maladies de la peau considérées, on citera de manière non exhaustive: déssèchement de lapeau, pellicules, acné, kératoses, psoriasis, eczéma, prurite, tâches séniles, lentigos, mélasmes, rides, verrues, lésions donnant des défectuosités de la peau, hyperpigmentation et hyperkératose de la peau, dermatoses inflammatoires, modification de la peau induite par le veillisement. On ajoutera à cette liste les cas oú un nettoyage de la peau est nécessaire.

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