C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 43/00 (2006.01) A61K 31/58 (2006.01) C07D 239/42 (2006.01) C07D 239/48 (2006.01) C07D 239/50 (2006.01) C07D 491/10 (2006.01)
Patent
CA 2136546
The invention relates to novel, therapeutically active 21-aminosteroids of formula (I) with pregnane skeleton, wherein two of X, Y and Z mean a nitrogen atom each and the third one is a methine group; R1 and R2 represent, independently from each other, a primary amino group bearing as substituent a branched-chain C4-8alkyl, -alkenyl or -alkynyl group, or a C4-10cyc- loalkyl group comprising 1 to 3 ring(s) and being optionally substituted by C1-3alkyl group(8); or R1 and R2 stand together for a spiro-heterocyclic secondary amino group containing at most 10 carbon atoms and optionally at least one oxygen atom as additional heteroatom; or one of R1 and R2 means an unsubstituted heterocyclic secondary amino group containing 4 to 7 carbon atoms and the other one is an above-identified primary amino group, an above-identified spiro-heterocyclic secon- dary amino group, or a heterocyclic secondary amino group containing 4 to 7 carbon atoms and substituted by C1-4alkyl group(s); and n is 1 or 2, as well as their acid addition salts and pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for the preparation of the above compounds. The compounds of formula (I) possess antioxidant, particularly lipid peroxidation-inhibiting effect, and therefore they may useful for the treatment of pathologic sequels of lipid peroxidation occurring in mammals, including man.
Balogh Gabor
Francsicsne Czinege Erzsebet
Gere Aniko
Gorog Sandor
Kiss Bela
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt.
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