Novel structural analogues of vitamin d

Details Novel structural analogues of vitamin d Novel structural analogues of vitamin d

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/045 (2006.01) A61K 31/335 (2006.01) A61K 31/59 (2006.01) C07C 35/22 (2006.01) C07C 35/27 (2006.01) C07C 43/188 (2006.01) C07C 47/192 (2006.01) C07C 47/198 (2006.01) C07C 47/28 (2006.01) C07C 47/36 (2006.01) C07C 47/37 (2006.01) C07C 49/242 (2006.01) C07C 49/29 (2006.01) C07C 49/517 (2006.01) C07C 49/687 (2006.01) C07C 49/743 (2006.01) C07C 49/755 (2006.01) C07C 57/26 (2006.01) C07C 59/01 (2006.01) C07C 62/00 (2006.01) C07C 69/03 (2006.01) C07C 309/63 (2006.01) C07D 303/14 (2006

Patent

CA 2166898

The present invention relates to analogues of vitamin D, which lack the combined presence of the trans-fused six-membered C-ring and of five-membered D-ring, but still possess a central part consisting of a subsituted chain of five atoms, atoms which correspond to positions 8, 14, 13 17 and 20 of vitamin D, and at the ends of which are connected, at position 20 a structural moiety representing part of the side chain of vitamin D or of an analogue of vitamin D, and at position 8 the .DELTA.(5,7)-diene moiety connected to the A-ring of the active 1-alpha-hydroxy metabolite or of an established vitamin D analogue, to their preparation process, to preparation intermediates, to pharmaceutical preparations comprising these compounds and to their use in medicine.

La présente invention se rapporte à des analogues de la vitamine D auxquels manque la présence combinée du noyau C hexagonal trans-condensé et du noyau D penthagonal, mais qui possède toujours une partie centrale se composant d'une chaîne substituée de 5 atomes, atomes qui correspondent aux positions 8, 14, 13, 17 et 20 de la vitamine D, et aux extrémités desquelles sont raccordées, à la position 20, une fraction structurale représentant une partie de la chaîne latérale de la vitamine D ou d'un analogue de celle-ci, et à la position 8, la fraction DELTA (5,7)-diène raccordée au noyau A du métabolite actif 1-alpha-hydroxy ou d'un analogue établi de la vitamine D. L'invention se rapporte également à leur procédé de préparation, aux intermédiaires de préparation, aux préparations pharmaceutiques comprenant ces composés et à leur utilisation en médecine.

Affiliated with

Also associated with

Rating

Novel structural analogues of vitamin d does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel structural analogues of vitamin d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel structural analogues of vitamin d will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1422365