C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/10 (2006.01) C12N 1/14 (2006.01) C12P 7/06 (2006.01) C12P 17/06 (2006.01) C12P 19/44 (2006.01)
Patent
CA 2315796
A process for producing a substance KF-1040A represented by formula (I), and another substance KF-1040B represented by formula (II), which comprises culturing microorganisms capable of producing the substances KF-1040A and KF-1040B, thus accumulating these KF-1040A and/or KF-1040B in the liquid culture and harvesting the same from the culture. Because of the activities of inhibiting diacyloglycerol transferase and sphingomyelinase, the above substances are useful in preventing and treating arteriosclerosis, obesity, thrombus, inflammation and immune function-related diseases.
La présente invention concerne une première substance Kf-1040A représentée par la formule (I), et une seconde substance KF-1040B représentée par la formule (II), comprenant des micro-organismes de culture pouvant produire les substances précitées, accumulant ainsi les KF-1040A et/ou KF-1040B dans le liquide de culture et les prélever de la culture précitée. Grâce à leur activités d'inhibition des diacyloglycérol transférase et sphingomyélinase, ces substances sont utilisées dans la prévention et le traitement le l'artériosclérose, de l'obésité, de la thrombus, des maladies inflammatoires, ainsi que des troubles liés aux fonctions immunitaires.
Masuma Rokuro
Omura Satoshi
Tomoda Hiroshi
Gowling Lafleur Henderson Llp
The Kitasato Institute
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