C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/695 (2006.01) C07D 211/22 (2006.01) C07D 211/70 (2006.01) C07D 211/72 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01) C07D 409/14 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2246727
The present invention relates to novel substituted N-methyl-N-(4-(piperidin-1- yl)-2-(aryl)butyl)benzamide derivatives of formula (I), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
La présente invention concerne des dérivés de N-méthyl-N-(4-pipéridin-1-yl)-2-(aryl)butyl)benzamides représentés par la formule générale (I) ainsi que certains de leurs stéréoisomères et certains de leurs sels galéniques. Ces produits conviennent particulièrement comme antagonistes des récepteurs de l'histamine et comme antagonistes des récepteurs de la tachyquinine. De tels antagonistes conviennent particulièrement au traitement des rhinites allergiques, notamment la rhinite saisonnière et la sinusite, des affections intestinales inflammatoires, notamment la maladie de Crohn et la rectocolite hémorragique, l'asthme, la bronchite et les vomissements.
Bratton Larry D.
Kane John M.
Kudlacz Elizabeth M.
Maynard George D.
Aventis Pharmaceuticals Inc.
Hoechst Marion Roussel Inc.
Osler Hoskin & Harcourt Llp
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