Novel substituted[1,4]benzodioxino[2,3-e]isoindole...

C - Chemistry – Metallurgy – 07 – D

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C07D 498/14 (2006.01) A61K 31/5365 (2006.01) A61P 35/00 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 491/14 (2006.01) C07D 491/22 (2006.01) C07D 498/22 (2006.01)

Patent

CA 2502488

The invention concerns compounds of formula (I), wherein: A is such as described in the description; Y represents a group selected among an oxygen atom or a methylene group; R¿2? represents a hydrogen atom, in which case: R¿3? represents a group selected among a hydrogen atom, a C¿1?-C¿6? linear or branched alkyl, aryl, linear or branched C¿1?-C¿6? arylalkyl group, or SO¿2?CF¿3?, or R¿2? and R¿3? form a bond; R¿1? represents a group selected among a hydrogen atom, a C¿1?-C¿6? linear or branched alkyl, aryl, linear or branched C¿1?-C¿6? arylalkyl group, or a linear or branched C¿1?-C¿6? alkylene chain¿; ?Z¿1? and Z¿2? represent each a hydrogen atom or Z¿1? and Z¿2? form together, with the carbon atoms bearing them, a phenyl group. The invention is useful for preparing medicines.

Composés de formule (I) dans laquelle : A est tel que définis dans la description, Y représente un groupement choisi parmi atome d'oxygène ou groupement méthylène, R2 représente un atome d'hydrogène, et dans ce cas R3 représente un groupement choisi parmi atome d'hydrogène, groupement alkyle (C1- C6) linéaire ou ramifié, aryle, arylalkyle (C1-C6) linéaire ou ramifié, ou SO2CF3, ou bien R2 et R3 forment une liaison, R1 représente un groupement choisi parmi atome d'hydrogène, groupement alkyle (C1-C6) linéaire ou ramifié, aryle, arylalkyle (C1-C6) linéaire ou ramifié, ou une chaîne alkylène (C1-C6) linéaire ou ramifié, Zl et Z2 représentent chacun un atome d'hydrogène ou, Zl et Z2 forment ensemble, avec les atomes de carbone qui les portent, un groupement phényle, Médicaments.

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