C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2247105
The present invention relates to novel substituted N-methyl-N-(4-(4-(1H- benzimidazol-2-yl-amino)piperidin-1-yl)-2-(aryl)butyl)benzamide derivatives of formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
La présente invention se rapporte à de nouveaux dérivés N-méthyl-N-(4-(4-(1H-benzimidazol-2-yl-amino)pipéridin-1-yl)-2-(aryl)butyl) benzamides substitués de la formule (1), à leurs stéréo-isomères et à leurs sels acceptables en pharmacologie; ils peuvent être utiles en tant qu'antagonistes des récepteurs de l'histamine et des récepteurs de la tachykinine. De tels antagonistes peuvent être utilisés pour traiter la rhinite allergique, y compris la rhinite saisonnière et la sinusite, les maladies inflammatoires des intestins, y compris la maladie de Crohn et la colite ulcéreuse, ainsi que l'asthme, la bronchite et les vomissements.
Bratton Larry D.
Dalton Christopher R.
Kane John M.
Kudlacz Elizabeth M.
Maynard George D.
Aventis Pharmaceuticals Inc.
Hoechst Marion Roussel Inc.
Osler Hoskin & Harcourt Llp
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