C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2241827
The present invention relates to novel 4-(1H-benzimidazol-2-yl) [1,4]diazepane derivatives of formula (1) and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
On décrit de nouveaux dérivés de 4-(1H-benzimidazol-2-yl) diazépane [1,4] de formule (1) et leurs stéréoisomères, ainsi que leurs sels pharmacologiquement acceptables, qui sont utiles comme antagonistes des récepteurs de l'histamine et de la tachykinine. Ces antagonistes sont utiles pour traiter les rhinites allergiques y compris le rhume des foins et la sinusite, les affectations intestinales inflammatoires y compris la maladie de Crohn et la rectocolite hémorragique, l'asthme, la bronchite et les vomissements.
Bratton Larry D.
Burkholder Timothy P.
Dalton Christopher R.
Kane John M.
Kudlacz Elizabeth M.
Aventis Pharmaceuticals Inc.
Hoechst Marion Roussel Inc.
Osler Hoskin & Harcourt Llp
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