Novel substituted aryl hydroxamic acids as metalloproteinase...

Details Novel substituted aryl hydroxamic acids as metalloproteinase... Novel substituted aryl hydroxamic acids as metalloproteinase...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/40 (2006.01) A61K 31/54 (2006.01) C07D 207/16 (2006.01) C07D 279/12 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2330108

The present application describes novel substituted aryl hydroxamic acids of formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring A is a 5-8 membered ring containing from 0-1 additional heteroatoms selected from N, O, and S, which are useful as metalloproteinase inhibitors and inhibitors of TNF.

L'invention concerne de nouveaux acides hydroxamiques à substitution aryle représentés par la formule (I) ou leurs sels acceptables sur le plan pharmaceutique, dans laquelle le noyau A est un noyau à 5-8 éléments contenant de 0 à 1 hétéroatomes supplémentaires sélectionnés dans N, O et S, utiles en tant qu'inhibiteurs de métalloprotéinase et qu'inhibiteurs de TNF.

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