C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61P 25/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2749495
The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I) wherein R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 and Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
La présente invention concerne de nouveaux dérivés substitués du benzoxazole, du benzimidazole, de l'oxazolopyridine et de l'imidazopyridine de formule (I) dans laquelle R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 et Z ont la signification définie dans les revendications. Les composés selon la présente invention sont utiles comme modulateurs de la gamma-secrétase. L'invention concerne en outre des procédés de préparation desdits nouveaux composés, des compositions pharmaceutiques comprenant lesdits composés comme principe actif ainsi que l'utilisation desdits composés comme médicament.
Berthelot Didier Jean-Claude
Bischoff Francois Paul
de Cleyn Michel Anna Jozef
Gijsen Henricus Jacobus Maria
Macdonald Gregor James
Gowling Lafleur Henderson Llp
Ortho-Mcneil-Janssen Pharmaceuticals Inc.
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