C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/10 (2006.01) A61K 31/4353 (2006.01) A61P 25/28 (2006.01) C07D 413/10 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2748862
The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical com-positions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
La présente invention porte sur des composés hétérocycliques bicycliques substitués de formule (I) dans laquelle Het1, Het2, A1, A2, A3 et A4 ont la signification définie dans les revendications. Les composés selon la présente invention sont utiles comme modulateurs de la gamma-sécrétase. L'invention porte en outre sur des procédés de préparation de tels nouveaux composés, sur des compositions pharmaceutiques comprenant lesdits composés en tant que principe actif ainsi que sur l'utilisation desdits composés comme médicament.
Berthelot Didier Jean-Claude
Bischoff Francois Paul
de Cleyn Michel Anna Jozef
Gijsen Henricus Jacobus Maria
Macdonald Gregor James
Gowling Lafleur Henderson Llp
Ortho-Mcneil-Janssen Pharmaceuticals Inc.
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