C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/4427 (2006.01) A61K 31/5386 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 498/10 (2006.01)
Patent
CA 2664112
The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.
La présente invention porte sur des dérivés de diaza-spiro-pyridinone substitués par aryle et hétéroaryle, ayant une activité d'hormone de concentration en mélanine (MCH) antagoniste, en particulier une activité MCH-1, selon la Formule générale (I), sur un sel d'addition avec les acides ou les bases pharmaceutiquement acceptables de ceux-ci, une forme de N-oxyde de ceux-ci ou un sel d'ammonium quaternaire de ceux-ci, les variables étant définies dans la revendication 1. L'invention concerne en outre leur préparation, des compositions les comprenant et leur utilisation en tant que médicament. Les composés selon l'invention sont utiles pour la prévention et/ou le traitement de troubles psychiatriques, comprenant, mais sans y être limités, l'anxiété, les troubles de l'alimentation, les troubles de l'humeur, tels que les troubles bipolaires et la dépression, les psychoses, telles que la schizophrénie, et les troubles du sommeil; l'obésité; le diabète; les troubles sexuels et les troubles neurologiques.
Alcazar-Vaca Manuel Jesus
Andres-Gil Jose Ignacio
Dautzenberg Frank Matthias
Linders Joannes Theodorus Maria
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
LandOfFree
Novel substituted diaza-spiro-pyridinone derivatives for use... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel substituted diaza-spiro-pyridinone derivatives for use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel substituted diaza-spiro-pyridinone derivatives for use... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1358226