C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/416 (2006.01) A61P 25/28 (2006.01) C07D 403/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2755467
The present invention is concerned with novel substituted indazole and aza- indazole derivatives of Formula (I), wherein R1, R2 , R3, R4, Y, A1, A2 , A3, A4, X1, X2, X3 and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
L'invention concerne de nouveaux dérivés substitués d'indazole et d'aza-indazole représentés par la formule (I), dans laquelle R1, R2, R3, R4, Y, A1, A2, A3, A4, X1, X2, X3 et Het1 sont tels que définis dans les revendications. Les composés de l'invention sont utilisés comme modulateurs de la gamma sécrétase. L'invention concerne également des procédés de préparation de ces nouveaux composés, des compositions pharmaceutiques comprenant lesdits composés en tant qu'ingrédient actif ainsi que l'utilisation des composés comme médicament.
Bischoff Francois Paul
Gijsen Henricus Jacobus Maria
Minne Garrett Berlond
Pieters Serge Maria Aloysius
Gowling Lafleur Henderson Llp
Janssen Pharmaceuticals Inc.
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