Novel substituted piperazine derivatives having tachykinin...

Details Novel substituted piperazine derivatives having tachykinin... Novel substituted piperazine derivatives having tachykinin...

C - Chemistry, Metallurgy

07

D

C07D 241/08 (2006.01) A61K 31/495 (2006.01) C07D 241/04 (2006.01) C07D 309/12 (2006.01) C07D 403/00 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2217006

The present invention relates to substituted piperazine derivatives (herein referred to as compounds or compounds of formula (1), or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin- mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.

La présente invention se rapporte à des dérivés de pipérazine substitués (désignés ci-après par composés ou composés de formule (1) ou à leurs stéréoisomères, ou leurs sels pharmaceutiquement acceptables ainsi qu'à leur utilisation comme antagonistes des récepteurs de la tachykinine. Ces antagonistes servent à traiter les maladies et les troubles induits par la tachykinine décrits par la présente invention, comprenant l'asthme, la toux et la bronchite.

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