Novel substituted piperidones as hsp inducers

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 211/74 (2006.01) A61K 31/45 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2695031

The present invention relates to novel compounds of formula (I) or (II), their pharmaceutically acceptable salts and their hydrates, solvates, stereoisomers, conformers, tautomers, polymorphs and prodrugs and also pharmaceutically acceptable compositions containing them Wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification. The compounds of the present invention are HSP inducers and by virtue of this effect, useful for the treatment of various diseases accompanying pathological stress. The present invention also relates to a process for the preparation of the said novel compounds. The invention also relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

La présente invention concerne de nouveaux composés de formule (I) ou (II), leurs sels pharmaceutiquement acceptables et leurs hydrates, solvats, stéréo-isomères, conformères, tautomères, polymorphes et promédicaments et également des compositions pharmaceutiquement acceptables les contenant, dans lesquels R1, R2, R3, R4, R5, R6 et R7 sont tels que définis dans la description. Les composés de la présente invention sont des inducteurs de HSP et grâce à cet effet, ils sont utiles pour le traitement de diverses maladies associées à un stress pathologique. La présente invention concerne également à un procédé pour la préparation desdits nouveaux composés. L'invention concerne également l'utilisation des composés mentionnés ci-dessus pour la préparation d'un médicament afin de les utiliser comme produits pharmaceutiques.

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