Novel substituted pyrazolo[1,5 a]-1,3,5-triazine derivatives...

Details Novel substituted pyrazolo[1,5 a]-1,3,5-triazine derivatives... Novel substituted pyrazolo[1,5 a]-1,3,5-triazine derivatives...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/53 (2006.01) A61K 31/70 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 231/00 (2006.01) C07D 251/00 (2006.01) C07H 17/02 (2006.01)

Patent

CA 2493402

The invention concerns novel substituted pyrazolo[1,5 <I>A</I>]-1,3,5-triazine derivatives and some of their structural analogues, and their therapeutic uses, more particularly for preventing and treating pathologies involving central and/or peripheral neuronal degeneration. The invention also concerns methods for preparing same and novel synthesis intermediates. The compounds of the invention correspond more particularly to general formulae (Ia) and (Ib).

L'invention concerne notamment de nouveaux dérivés de pyrazolo[1,5-a]-1,3,5- triazines ainsi que certains de leurs analogues structuraux et leurs applications dans le domaine thérapeutique tout particulièrement pour la prévention et le traitement de pathologies impliquant une dégénérescence des neurones centraux et/ou périphériques. Elle concerne également des procédés pour leur préparation et de nouveaux intermédiaires de synthèse. Les composés de l'invention répondent plus particulièrement aux formules générales (Ia) et (Ib).

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