Novel substituted salicylic acids

Details Novel substituted salicylic acids Novel substituted salicylic acids

C - Chemistry, Metallurgy

07

D

C07D 213/76 (2006.01) A61K 31/395 (2006.01) C07D 231/42 (2006.01) C07D 233/88 (2006.01) C07D 237/20 (2006.01) C07D 239/42 (2006.01) C07D 239/69 (2006.01) C07D 241/22 (2006.01) C07D 249/02 (2006.01) C07D 261/16 (2006.01) C07D 263/50 (2006.01) C07D 275/03 (2006.01) C07D 277/82 (2006.01)

Patent

CA 2123697

A compound of the formula Het-NR-SO2-Ph2-A-Ph1 (COOH)(OH) and tautomic form, salts, solvates, C1-6 alkyl esters and pharmaceutical compositions of the compound. Ph1 and Ph2 are benzene rings with the proviso that carboxy and hy- droxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A is a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl. The invention also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.

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