C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 473/30 (2006.01) C07D 473/40 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2086546
2086546 9201697 PCTABS00010 Substituted thiazolyl and substituted pyridinyl derivatives of formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein -A1=A2-A3=A4- is a bivalent radical having the formula -CH=CH-CH=CH- (a-1), -N=CH-CH=CH- (a-2), -CH=N-CH=CH- (a-3), -CH=CH-N=CH- (a-4), -CH=CH-CH=N- (a-5), -N=CH-N=CH- (a-6) or -CH=N-CH=N- (a-7); B represents NR1, CH2, O, S, SO or SO2 wherein R1 is hydrogen or C1-4alkyl; R is a radical of formula (b-1) or (b-2); wherein D is C1-4alkanediyl; R2 is C1-6alkyl; n is 0, 1 or 2; L is hydrogen; C1-12alkyl; C3-6cycloalkyl; C3-6alkenyl optionally substituted with aryl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; arylcarbonyl; aryl C1-6alkyloxycarbonyl; or a radical of formula -Alk-R3 (c-1); -Alk-Y-R4 (c-2); -Alk-Z1-C(=X)-Z2-R5 (c-3); or -CH2-CHOH-CH2-O-R6 (c-4); have antiallergic properties. Compositions containing the same and methods of treating warm-blooded animals suffering from allergic diseases.
Diels Gaston S. M.
Janssens Frans E.
Sommen Francois M.
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Naamloze Vennootschap
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