Novel substitution mutant receptors and their use in a...

Details Novel substitution mutant receptors and their use in a... Novel substitution mutant receptors and their use in a...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 1/00 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2445796

This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

L'invention concerne le domaine de la biotechnologie ou du génie génétique. Plus précisément, l'invention concerne le domaine de l'expression génique. Plus particulièrement encore, l'invention concerne des nouveaux récepteurs de mutants de substitution et l'utilisation de ceux-ci dans un système d'expression génique inductible à base de récepteurs nucléaires du groupe H, ainsi que des procédés de modulation de l'expression d'un gène dans une cellule hôte destinés à des applications, telles qu'une thérapie génique, une production à grande échelle de protéines et d'anticorps, des essais de criblage à base de cellules à rendement élevé, la génomique fonctionnelle et la régulation de caractères dans des organismes transgéniques.

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