Novel substrate for rpn 11 enzymatic activity

Details Novel substrate for rpn 11 enzymatic activity Novel substrate for rpn 11 enzymatic activity

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 38/17 (2006.01) C07K 19/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2609271

The present application provides peptides that serve as substrates for proteasome enzymatic activity, e.g., the enzymatic activity of Rpn11, a metalloprotease of the 19S regulatory particle. The present application also provides methods and compositions employing the peptide substrates.

La présente invention concerne des peptides servant de substrat pour l'activité enzymatique du protéasome, c'est-à-dire l'activité enzymatique de Rpn11, une métalloprotéase de la particule régulatrice 19S. sont également décrites des compositions et des méthodes utilisant ces substrats peptidiques.

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