C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/16 (2006.01) A61K 31/401 (2006.01) A61K 31/445 (2006.01) A61P 31/00 (2006.01) C07D 207/06 (2006.01) C07D 207/08 (2006.01) C07D 207/09 (2006.01) C07D 207/14 (2006.01) C07D 211/60 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2393825
Novel hydroxamic acid compounds of Formula (I) are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.
L'invention concerne des nouveaux composés de la formule (I) à base d'acide hydroxamique. Ces hydroxamates inhibent la peptide déformylase (PDF), une enzyme présente dans les procaryotes, et ils sont donc utiles en tant qu'antimicrobiens et antibiotiques. Les composés de l'invention possèdent un pouvoir d'inhibition sélective de la peptidyle déformylase, par rapport à d'autres métalloprotéinases, telles que les métalloprotéinases matricielles (MMP). L'invention concerne encore des procédés de synthèse et d'utilisation de ces composés.
Jacobs Jeffrey W.
Jain Rakesh
Ni Zhi-Jie
Patel Dinesh V.
Yuan Zhengyu
Barrigar Intellectual Property Law
Versicor Inc.
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