A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 37/00 (2006.01) A01N 37/10 (2006.01) A01N 37/30 (2006.01) A01N 37/44 (2006.01) A01N 43/02 (2006.01) A01N 43/16 (2006.01) A01N 43/64 (2006.01) A01N 57/00 (2006.01) C07C 57/34 (2006.01) C07C 57/38 (2006.01) C07C 57/40 (2006.01) C07C 57/46 (2006.01) C07C 57/48 (2006.01) C07C 57/58 (2006.01) C07C 59/48 (2006.01) C07C 59/52 (2006.01) C07C 59/64 (2006.01) C07C 59/68 (2006.01) C07C 63/313 (2006.01) C07D 209/86 (2006.01) C07D 211/70 (2006.01) C07D 213/55 (2006.01) C07D 239/02 (2006.01) C07D 307/02 (2006.01) C0
Patent
CA 2388077
This invention relates to novel substituted succinic acid metallo-.beta.- lactamase inhibitors which are useful potentiators of .beta.-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections in animals or humans which comprises administering, together with a .beta.-lactam antibiotic, a therapeutically effective amount of a compound of formula (I) including pharmaceutically acceptable salts, prodrugs, anhydrides, and solvates thereof.
Cette invention a trait à de nouveaux inhibiteurs de métallo-.beta.-lactamase à base d'acide succinique substitué qui se révèlent être d'utiles potentialisateurs d'antibiotiques .beta.-lactame. Cette invention porte ainsi sur une méthode de traitement d'infections bactériennes chez l'humain ou l'animal consistant à administrer en même temps qu'un antibiotique .beta.-lactame, une quantité efficace du point de vue thérapeutique d'un composé correspondant à la formule (I), y compris ses sels acceptables du point de vue pharmaceutique, ses promédicaments, ses anhydrides et ses solvates.
Balkovec James M.
Epstein-Toney Jeffrey H.
Greenlee Mark L.
Hammond Gail
Olson Steven H.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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