Novel sucrose ligands, methods for their preparation,...

Details Novel sucrose ligands, methods for their preparation,... Novel sucrose ligands, methods for their preparation,...

C - Chemistry, Metallurgy

07

H

C07H 23/00 (2006.01) A23L 1/05 (2006.01) A61K 31/70 (2006.01) A61K 49/06 (2006.01) C07H 9/02 (2006.01)

Patent

CA 2139414

The invention relates to novel sucrose ligands, methods for their preparation and their use as ligands for complexation with metals or metal containing compounds, as bulking agents or to make novel crosslinking agents. Bis(platinum) complexes and tris(platinum) complexes derived from 6,6'-diamino-6,6'-dideoxy- 1',2-anhydrosucrose, 1',6,6'-triamino- 1',6,6'-trideoxy- 2,3,3',4,4'-penta-O-methylsucrose, and 6,6'-diamino-6,6'-dideoxy-1',2,3,3',4,4'-hexa-O-methylsucrose are taught which may be used for the treatment of cancers including testicular cancer. Mono(platinum) complexes derived from 6,6'-diamino-6,6'-dideoxy- 1',2,3,3',4,4'-hexa-O-methylsucrose are also taught which may be used as sensitizers during radiation therapy or tumor imaging.

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