C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/14 (2006.01) A61K 31/70 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2535800
Sulfenamide oxide compounds of general formula (I) are disclosed wherein A, R1, R2, X1, X1~, X2, X2~, X3, X3~, X4, X4~, X5 and X5~ define a variety of variables and wherein q is 0 or 1 and p is 1 or 2. The compounds disclosed in the examples are galactofuranosyl and glucofuranosyl sulfenamide oxide compounds wherein the variable A is oxygen. Methods of synthesis of compounds of general formula (I), pharmaceutical compositions containing them and methods of using them to treat patients suffering a microbial infection are also disclosed.
L'invention concerne des composés d'oxyde sulfenamide représentés par la formule générale (I) dans laquelle A, R¿1?, R¿2?, X¿1?, X¿1?', X¿2?, X¿2?', X¿3?, X¿3?', X¿4?, X¿4?', X¿5? et X¿5?' désignent diverses variables, q vaut 0 ou 1 et p vaut 1 ou 2. Les composés présentés dans les exemples sont des composés d'oxyde sulfenamide galactofuranosyl et glucofuranosyl dans lesquels la variable A désigne de l'oxygène. L'invention concerne également des méthodes de synthèse de composés représentés par la formule générale (I), des compositions pharmaceutiques contenant ces composés et des méthodes utilisant ces composés et ces compositions, destinées au traitement de patients souffrant d'une infection microbienne.
Davis Christopher Bonner
Hartnell Regan David
Madge Paul David Orr
Thomson Robin Joy
von Itzstein Laurence Mark
Griffith University
Kirby Eades Gale Baker
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