Novel sulfenamides

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 15/14 (2006.01) A61K 31/70 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2535802

Sulfenamide compounds of general formula (I) are disclosed wherein A, R1,R2, X1, X1~, X2, X2~, X3, X3~, X4, X4~, X5 and X5~ define a variety of variables and q is 0 or 1. The compounds of the examples are galactofuranosyl and arabinofuranosyl compounds wherein the variable A is oxygen. Methods for the synthesis of compounds of general formula (I), pharmaceutical compositions them and methods of using them to treat patients suffering a microbial infection are also disclosed.

La présente invention porte sur des composés sulfénamides représentés par la formule générale (1) dans laquelle A, R¿1, ?R¿2?, X¿1?, X¿1?', X¿2?, X¿2?', X¿3?, X¿3?', X¿4?, X¿4?', X¿5? et X¿5?' définissent une multitude de variables et q désigne 0 ou 1. Les composés des exemples donnés sont des composés galactofuranosyle et arabinofuranosyle dans lesquels la variable A représente l'oxygène. Cette invention concerne également des procédés de synthèse des composés représentés par la formule générale (I), des compositions pharmaceutiques les contenant, ainsi que des procédés d'utilisation de ces composés pour traiter des patient souffrant d'une infection microbienne.

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