Novel sulfonamide compounds and uses thereof

Details Novel sulfonamide compounds and uses thereof Novel sulfonamide compounds and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 311/21 (2006.01) A61K 31/18 (2006.01) A61P 25/00 (2006.01) C07C 323/41 (2006.01) C07D 207/08 (2006.01) C07D 211/24 (2006.01) C07D 277/06 (2006.01) C07D 295/12 (2006.01) C07D 311/20 (2006.01)

Patent

CA 2366919

In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substituted or unsubstituted hydrocarbyl moieties, substituted or unsubstituted heterocycle moieties, polycyclic moieties, halogen, alkoxy, ether, ester, amide, sulfonyl, sulfonamidyl, sulfide, carbamate, and the like. Invention compounds are capable of a wide variety of uses. For example sulfonamide compounds can act to modulate production of amyloid .beta. protein and are useful in the prevention or treatment of a variety of diseases. Pharmaceutical compositions containing invention compounds are also provided. Such compositions have wide utility for the prevention or treatment of a variety of diseases.

L'invention concerne une nouvelle classe de composés de sulfonamide, qui renferment un groupe sulfonamide central. Des fractions variables reliées à l'atome de soufre et à l'atome d'azote du groupe sulfonamide présentent des fractions hydrocarbyle substituées ou non substituées, des fractions hétérocycliques substituées ou non substituées, des fractions polycycliques, halogène, alcoxy, éther, ester, amide, sulfonyle, sulfonamidyle, sulfure, carbamate, et autres. Les composés considérés offrent une large variété d'utilisations. Par exemple, ils peuvent moduler la production de protéine bêta-amyloïde et sont utiles pour prévenir ou traiter un certain nombre de maladies. L'invention concerne également des compositions pharmaceutiques renfermant les composés en question. Lesdites compositions ont donc une grande utilité pour la prévention ou le traitement d'une variété de maladies.

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