A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/00 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 31/505 (2006.01) C07C 303/00 (2006.01) C07D 209/12 (2006.01) C07D 211/84 (2006.01) C07D 239/02 (2006.01) C07D 261/04 (2006.01)
Patent
CA 2567835
Disclosed herein are carbonyl compounds of having the structural formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
L'invention concerne des composés carbonyle représentés par la formule structurelle (I) ou un sel, amide, ester ou promédicament pharmaceutiquement acceptable de ces composés. L'invention concerne également des méthodes et des compositions permettant de traiter des états pathologiques, notamment les cancers, les maladies auto-immunes, les lésions tissulaires, les troubles du système nerveux central, les troubles neurodégénératifs, la fibrose, les troubles osseux, les troubles de répétition de la polyglutamine, les anémies, les thalassémies, les affections inflammatoires, les affections cardiovasculaires et les troubles dans lesquels l'angiogenèse joue un rôle dans la pathogenèse, au moyen des composés selon l'invention. En outre, L'invention concerne également des méthodes de moduler l'activité de histone désacétylase (HDAC).
Hassig Christian
Hoffman Timothy
Lawrence Charles
Malecha James
Noble Stewart
Kalypsys Inc.
Mcfadden Fincham
LandOfFree
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