A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/10 (2006.01) A23L 1/29 (2006.01) A61K 31/22 (2006.01) C07C 317/04 (2006.01) C07C 317/06 (2006.01) C07C 317/12 (2006.01) C07C 321/14 (2006.01) C07C 321/18 (2006.01) C07C 321/22 (2006.01) A61P 3/04 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2730958
The present invention relates to lipid compounds of the general formula (I): (I) wherein R1 is selected from a C10-C22 alkyl, a C10-C22 alkenyl having 1-6 double bonds, and a C10-C22 alkynyl having 1-6 triple bonds;R2 and R3 are the same or different and may be selected from a group of different substituents; Y is selected from sulphur, sulfoxide, and sulfone; and X represents a carboxylic acid or a derivative thereof, a carboxylic ester, a carboxylic anhydride or a carboxamide; or a pharmaceutically acceptable salt, complex or solvate thereof. The invention also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.
La présente invention porte sur des composés lipidiques selon la formule générale (I) : (I) dans laquelle R1 est choisi parmi un alkyle en C10-C22, un alcényle en C10-C22 ayant 1 à 6 doubles liaisons et un alcynyle en C10-C22 ayant 1 à 6 triples liaisons; R2 et R3 sont identiques ou différents et peuvent être choisis dans un groupe de différents substituants; Y est choisi parmi sulfure, sulfoxyde et sulfone; et X représente un acide carboxylique ou un dérivé de celui-ci, un ester carboxylique, un anhydre carboxylique ou un carboxamide; ou un sel pharmaceutiquement acceptable, complexe ou solvate de ceux-ci. L'invention porte également sur des compositions pharmaceutiques et sur des compositions lipidiques comprenant de tels composés, et sur de tels composés pour utilisation en tant que médicaments ou pour une utilisation en thérapie, en particulier pour le traitement de maladies relatives au domaine des maladies cardiovasculaires, métaboliques et inflammatoires.
Brændvang Morten
Hovland Ragnar
Kristin Holmeide Anne
Blake Cassels & Graydon Llp
Pronova Biopharma Norge As
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