Novel synthesis of irbesartan

Details Novel synthesis of irbesartan Novel synthesis of irbesartan

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) C07D 235/00 (2006.01) C07D 235/02 (2006.01) C07D 257/00 (2006.01)

Patent

CA 2513373

Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4'-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene- 4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.

L'invention concerne un procédé de préparation d'irbésartan par réaction de couplage de Suzuki et un nouveau produit intermédiaire, le 2-butyl-3-(4'-bromobenzyle)-1,3-diazaspiro[4.4]none-1-ène-4-one, approprié pour ledit processus. Ce nouveau processus comprend l'étape de la réaction d'un tel produit intermédiaire avec un acide imidazolephénylboronique protégé.

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