A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 43/04 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2560969
The invention is directed to novel compounds of formulae (I), (II) and (III): wherein X is O or NH; R3 is OH or a monosaccharide and R4 is hydrogen, or R3 is hydrogen and R4 is OH or a monosaccharide; R5 is hydrogen or a monosaccharide; and pharmaceutically acceptable salts or esters thereof. The invention is also directed to the use of the compounds both directly and as immune adjuvants for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the intermediates which can be used to make these novel compounds.
L'invention concerne de nouveaux composés de formules (I), (II) et (III), dans lesquelles X désigne O ou NH; R?3¿ désigne OH ou un monosaccharide et R?4¿ désigne hydrogène, ou R?3¿ désigne hydrogène et R?4¿, OH ou un monosaccharide; R?5¿ désigne hydrogène ou un monosaccharide, ainsi que leurs sels ou esters pharmaceutiquement acceptables. L'invention concerne l'utilisation de ces composés à la fois directement et comme adjuvants immunes pour traiter le cancer, des maladies infectieuses et des maladies auto-immunes. L'invention concerne également des synthèses des produits intermédiaires pouvant s'utiliser pour produire ces nouveaux composés.
Chen Guangwu
Franck Richard
Tsuji Moriya
New York University
Robic
The Research Foundation Of The City University Of New York
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