Novel synthetic isohirudins with improved stability

Details Novel synthetic isohirudins with improved stability Novel synthetic isohirudins with improved stability

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/58 (2006.01) A61P 7/02 (2006.01) C07K 1/14 (2006.01) C07K 14/815 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2084552

The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formulation as directly injectable solution ready for use.

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