C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 38/10 (2006.01) A61P 9/08 (2006.01) C07K 7/08 (2006.01) C07K 7/22 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2380354
Tachykinin peptides isolated and purified from the posterior salivary gland of common octopus which is a mollusc. These tachykinin peptides, which provide a new approach for developing drugs and pesticides through studies on the structural activity correlation at the molecular level, are characterized by: (1) having 12 amino acid residues; (2) having Lys at the N-terminus; and (3) having the following amino acid sequence (I) consisting of 5 amino acids from the C-terminus: -Phe-Xaa-Gly-Leu-Met-NH2 wherein Xaa represents Val, Ile, Phe or Tyr. Among all, novel peptides having the following amino acid sequences (1) H-Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Val-Gly-Leu-Met-NH2; and (2) H-Lys-Pro- Pro-Ser-Ser-Ser-Glu-Phe-Ile-Gly-Leu-Met-NH2.
L'invention concerne des peptides de la tachykinine isolés et purifiés provenant de la glande salivaire postérieure d'un mollusque, le poulpe commun. Ces peptides de la tachykinine, qui offrent une nouvelle approche pour l'élaboration de médicaments et de pesticides grâce à des études sur la corrélation de l'activité structurale au niveau de la molécule, se caractérisent en ce qu'ils présentent (1) 12 résidus d'acides aminés; (2) Lys à la N-terminaison; et (3) la séquence d'acide aminé (I) constituée de 5 acides aminés à partir de la C-terminaison: -Phe-Xaa-Gly-Leu-Met-NH¿2?. Les nouveaux peptides présentent notamment les séquences d'acides aminés suivantes: (1) H-Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Val-Gly-Gleu-Met-NH¿2?; et (2) H-Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Ile-Gly-Leu-Met-NH¿2?.
Iwakoshi Eiko
Kuroda Kyoko
Minakata Hiroyuki
Smart & Biggar
Suntory Holdings Limited
Suntory Limited
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