A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/496 (2006.01) A61K 9/70 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/16 (2006.01) A61K 47/22 (2006.01) A61K 47/32 (2006.01) A61P 25/18 (2006.01)
Patent
CA 2653827
It is intended to provide a preparation for percutaneous administration of 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine (Compound A), which inhibits the generation of a metabolite and is capable of continuously maintaining a blood drug level. Specifically, a tape preparation comprising an adhesive layer formed on one surface of a support, characterized in that the adhesive layer contains (1) Compound A or a physiologically acceptable acid addition salt thereof, and (2) an acrylic adhesive, or (1) Compound A or a physiologically acceptable acid addition salt thereof, (2) an acrylic adhesive, and (3) a permeation enhancer is provided.
La présente invention concerne une préparation destinée à l'administration percutanée de 2-(4-éthyl-1-pipérazinyl)-4-(4-fluorophényl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine (composé A), qui inhibe la génération d'un métabolite et qui est capable de maintenir en continu le taux sanguin d'un médicament. L'invention concerne spécifiquement une préparation en ruban qui comprend une couche adhésive formée sur une surface d'un support, caractérisée par le fait que la couche adhésive contient (1) le composé A ou un de ses sels d'addition d'acide physiologiquement acceptable et (2) un adhésif acrylique, ou (1) le composé A ou un de ses sels d'addition d'acide physiologiquement acceptable, (2) un adhésif acrylique et (3) un stimulateur de perméation.
Maeda Hiroo
Ohara Naoki
Dainippon Sumitomo Pharma Co. Ltd.
Kirby Eades Gale Baker
LandOfFree
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