C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C07K 14/16 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2376665
The present invention provides a panel of transcriptional activator fusion proteins which comprises both tetracycline controlled transactivator proteins and reverse tetracycline transactivator proteins. These transactivators have novel phenotypes such as alterred basal transcriptional activity in the absence of doxycycline, altered induced transcriptional activity in the presence of doxycycline, or differential induction by tetracycline and analogs of tetracycline.
La présente invention concerne un ensemble de protéines de fusion d'activation transcriptionnelle qui comprend à la fois des protéines transactivatrices à régulation par tétracycline et des protéines transactivatrices à régulation inverse par tétracycline. Ces transactivateurs présentent de nouveaux phénotypes tels qu'une activité transcriptionnelle basale altérée en l'absence de doxycycline, une activité transcriptionnelle induite altérée en présence de doxycycline, ou une induction différentielle par la tétracycline et ses analogues.
Bujard Hermann
Hillen Wolfgang
Urlinger Stefanie
Bujard Hermann
Goudreau Gage Dubuc
Hillen Wolfgang
Tet Systems Holding Gmbh & Co. Kg
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