C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 49/747 (2006.01) A61K 31/122 (2006.01) A61K 31/352 (2006.01) A61K 31/357 (2006.01) A61K 31/445 (2006.01) A61P 5/24 (2006.01) A61P 35/00 (2006.01) C07C 45/74 (2006.01) C07C 49/683 (2006.01) C07C 49/697 (2006.01) C07C 49/755 (2006.01) C07C 65/40 (2006.01) C07C 225/22 (2006.01) C07D 311/22 (2006.01) C07D 317/54 (2006.01) C07D 319/18 (2006.01) C07D 407/06 (2006.01)
Patent
CA 2250258
The present invention provides new tetralone or benzopyranone derivatives and a method for producing the derivatives useful for a therapeutic agent for preventing and/or treating hormone dependent diseases. The present invention is a new tetralone or benzopyranone derivative represented by a particular general formula (I) (see formula I) wherein R1 represents a hydroxy group, an alkyloxy group or an aralkyloxy group, R2-R6 represent hydrogen, a hydroxy group, a straight or branched alkyloxy or aralkyloxy group having 1-6 carbon atoms, a halogen, an amino group or an alkylene dioxy group joined at R2 and R3, R3 and R4, R4 and R5, R5 and R6, and A represents a methylene or oxygen, but provided that when R1 is methoxy, R2-R6 are all hydrogens and A is the methylene. In the production, a particular tetralone or benzopyranone compound and a particular benzaldehyde compound are reacted.
Cette invention se rapporte à de nouveaux dérivés de tétralone ou de benzopyranone utiles en tant qu'agents préventifs et/ou remèdes de diverses maladies liées à des hormones mâles ou femelles. Ces dérivés sont représentés par la formule générale (I) dans laquelle R1 et R2 sont chacun hydrogène, hydroxy, alkyloxy ou aralkyloxy; R3 à R7 sont chacun hydrogène, hydroxy, alkyle C1-6 linéaire ou ramifié, alkyloxy, aralkyloxy, halogéno ou amino, ou bien R3 et R4, R4 et R5, R5 et R6, ou R6 et R7 sont liés les uns aux autres de manière à former un alkylènedioxy; et A est méthylène ou oxygène. On fabrique ces dérivés en faisant réagir des dérivés spécifiques de tétralone ou de benzopyranone avec des dérivés spécifiques de benzaldéhyde.
Nakakoshi Masamichi
Nakamura Junji
Nakayama Shoji
Yoshihama Makoto
Daiichi Pharmaceutical Co. Ltd.
Finlayson & Singlehurst
Snow Brand Milk Products Co. Ltd.
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