Novel th2-specific molecules and uses thereof

Details Novel th2-specific molecules and uses thereof Novel th2-specific molecules and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2346496

Novel Th2-specific polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Th2-specific proteins, the invention further provides isolated Th2-specific fusion proteins, antigenic peptides, and anti-Th2-specific antibodies. The invention also provides Th2- specific nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a Th2- specific gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne de nouveaux polypeptides, protéines et molécules d'acide nucléique spécifiques de Th2. Outre les protéines isolées et de pleine longueur, spécifiques de Th2, la présente invention décrit aussi des protéines de fusion et des peptides antigéniques spécifiques de Th2, ainsi que des anticorps spécifiques anti-Th2. L'invention concerne également des molécules d'acide nucléique spécifiques de Th2, des vecteurs d'expression recombinés contenant une molécule d'acide nucléique de l'invention, des cellules hôtes dans lesquelles on a introduit les vecteurs d'expression, et des animaux transgéniques non humains dans lesquels on a introduit ou dissocié un gène spécifique de Th2. L'invention concerne également des méthodes diagnostiques, thérapeutiques et de criblage faisant intervenir les compositions selon l'invention.

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