C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 49/115 (2006.01) A61K 31/12 (2006.01) A61K 31/35 (2006.01) C07C 49/23 (2006.01) C07C 49/76 (2006.01) C07D 311/78 (2006.01) C07D 335/04 (2006.01)
Patent
CA 2530581
The present invention is directed to compounds having the structure (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic dis-eases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.
L'invention concerne des composés représentés par la formule (I) dans laquelle R1, R2, R3, R4, R5 et m sont définis. Lesdits composés sont de nouveaux agents thérapeutiques permettant de traiter le cancer, les troubles métaboliques et le affections cutanées chez les sujets mammifères. Ces composés sont également utilisés comme modulateurs d'expression génique. Ils exercent leur activité par interférence avec certaines cascades de transduction de signaux cellulaires. Ils sont, en outre, utilisés pour réguler la différentiation cellulaire et des processus de cycles cellulaires commandés ou régulés au moyen d'hormones ou de cytokines variées. L'invention concerne, en particulier, des composés induisant l'apoptose de cellules cancéreuses pouvant donc être utilisés pour traiter ou prévenir un cancer, notamment des cancers avancés et des cellules précancéreuses. L'invention concerne enfin des compositions pharmaceutiques et des méthodes permettant de traiter une maladie chez les mammifères.
Hong Borcherng
Sarshar Sepehr
Tse Bruno
Auspex Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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