C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61P 1/00 (2006.01) C07K 14/195 (2006.01) C07K 14/205 (2006.01) C07K 16/12 (2006.01) C12Q 1/04 (2006.01) G01N 33/537 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2399276
The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganisms. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis, which encodes an immunogenic polypeptide that is particularly useful as an antigen in a vaccine preparation for conferring humoral immunity againstLawsonia intracellularis and related pathogens in animal hosts, wherein said polypeptide is selected from the group consisting of flhB, fliR, ntrC, glnH, motA, motB, tlyC, ytfM, and ytfN polypeptides, or a homologue, analogue or derivative of any one or more of said polypeptides. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.
L'invention concerne de manière générale des compositions thérapeutiques pour le traitement et/ou la prévention d'états maladifs des intestins chez les animaux et les oiseaux, causés ou exacerbés par <i>Lawsonia intracellularis</i> ou similaire ou par un micro-organisme apparenté. Plus spécifiquement, cette invention concerne un nouveau gène dérivé de <i>Lawsonia intracellularis</i>, qui code pour un polypeptide immunogène particulièrement utile en tant qu'antigène dans une préparation de vaccin permettant de conférer l'immunité humorale contre <i>Lawsonia intracellularis</i> et des pathogènes apparentés chez des animaux hôtes. Ledit polypeptide est choisi dans le groupe comprenant les polypeptides flhB, fliR, ntrC, glnH, motA, motB, tlyC, ytfM, et ytfN, ou un homologue, analogue ou dérivé d'un ou plusieurs desdits polypeptides. Cette invention concerne également des procédés pour le traitement et/ou la prévention de tels états maladifs des intestins, ainsi que des agents de diagnostic et des procédures permettant de détecter la présence de <i>Lawsonia intracellularis</i> ou similaire ou de micro-organismes apparentés.
Good Robert Trygve
King Kendall Wayne
Rosey Everett Lee
Strugnell Richard Anthony
Agriculture Victoria Services Pty Ltd.
Australian Pork Limited
Pfizer Products Inc.
Smart & Biggar
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