C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 38/45 (2006.01) A61K 38/48 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2414210
The present invention relates generally to a sphingosine kinase variant and to derivatives, analogues, chemical equivalents and mimetics thereof exhibiting reduced catalytic activity and, more particularly, to sphingosine kinase variants which exhibit a reduced capacity to phosphorylate sphingosine to sphingosine-1-phosphate. The present invention also contemplates genetic sequences encoding said sphingosine kinase variants and derivatives, analogues and mimetics thereof. The variants of the present invention are useful in a range of therapeutic and prophylactic applications.
La présente invention concerne généralement un variant de sphingosine kinase et des dérivés, des analogues, des équivalents chimiques et des mimétiques dudit variant dont l'activité catalytique est réduite et des variants de sphingosine kinase qui présentent une aptitude réduite à phosphoryler la sphingosine en sphingosine-1-phosphate. Cette invention concerne également des séquences génétiques codant pour des variants de ladite sphingosine kinase ainsi que des dérivés, des analogues et des mimétiques de ces variants. Les variants couverts par la présente invention conviennent bien pour diverses applications thérapeutiques et prophylactiques.
Moretti Paul
Pitson Stuart
Vadas Mathew
Wattenberg Binks
Xia Pu
Fetherstonhaugh & Co.
Medvet Science Pty Ltd
LandOfFree
Novel therapeutic molecular variants and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel therapeutic molecular variants and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel therapeutic molecular variants and uses thereof will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1669283