A - Human Necessities – 61 – P
Patent
A - Human Necessities
61
P
A61P 43/00 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 15/10 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 21/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2488356
The invention relates to a novel use of extracts of the genus Polypodiaceae for the treatment of fibrotic diseases, diseases caused by an overexpression of the components of the extracellular matrix or by an overexpression of Transforming Growth Factor (TFG-.szlig.), e.g. scleroderma, pulmonary fibrosis, atherosclerosis, medullary fibrosis, hepatic fibrosis, pancreatic fibrosis, renal fibrosis, cardiac fibrosis, Dupuytren's disease and, in particular, Peyronie's disease. The invention also relates to the inhibition of the components of the extracellular matrix in vitro and the reduction of the fibrosis in the tunica albuginea of the penis and the size of the collagen plate in patients with Peyronie's disease using Polypodium extracts. In a preferred mode, the Polypodium extracts are obtained by extraction with a polar solvent from the rhizomes of Polypodium leucotomos.
L'invention concerne une nouvelle utilisation d'extraits du genre des Polypodacées en vue du traitement des maladies fibrotiques, des maladies produites par une surexpression des composants de la matrice extracellulaire et par une surexpression du facteur de croissance transformant (TGF-.beta.); par exemple, la sclérodermie, la fibrose pulmonaire, l'athérosclérose, la fibrose médullaire, la fibrose hépatique, la fibrose pancréatique, la fibrose rénale, la fibrose cardiaque, la maladie de Dupuytrem et, plus précisément, la maladie de La Peyronie. L'invention concerne l'inhibition des composants de la matrice extracellulaire in vitro, la réduction de la fibrose de la tunique albuginée du pénis et de la taille de la plaque en collagène chez les patients souffrant de la maladie de La Peyronie grâce aux extraits de Polypodium. Dans un mode de réalisation préféré, les extraits de Polypodium sont obtenus par extraction avec un dissolvant polaire à partir des rhizomes du Polypodium leucomotos.
Especialidades Farmaceuticas Centrum S.a.
Finlayson & Singlehurst
Quintanilla Almagro Eliseo
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