Novel therapeutic use of viral inflammation modulatory...

Details Novel therapeutic use of viral inflammation modulatory... Novel therapeutic use of viral inflammation modulatory...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/11 (2006.01)

Patent

CA 2374681

The present invention provides a method of blocking xenograft rejection in a patient in need of such treatment by administering to said patient a virally- encoded complement control protein, referred to as the inflammation modulatory protein (<i>IMP</i>). The present invention further provides pharmaceutical compositions for the prevention or treatment of xenograft rejection comprising the IMP protein, alone or in combination with other immunosuppressive agents.

L'invention concerne une technique permettant de bloquer le rejet d'une xénogreffe chez un patient nécessitant un tel traitement. Cette technique consiste à administrer à ce patient une protéine régulatrice d'un complément viralement codée, dénommée protéine modulatrice d'inflammation (IMP). L'invention concerne également des compositions pharmaceutiques comprenant la protéine modulatrice d'inflammation, seule ou en combinaison avec d'autres agents immunosuppresseurs, et utilisées pour prévenir ou traiter le rejet de xénogreffe,.

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