A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/17 (2006.01) C07K 14/215 (2006.01)
Patent
CA 2721635
The present inventions relates to the use of an isolated nucleic acid molecule comprising a nucleotide sequence coding for a hyperpolarizing light-gated ion channel or pump gene from an archeon or for a light-active fragment of said gene, or the nucleotide sequence complementary to said nucleotide sequence, for treating or ameliorating blindness. The light-gated ion channel or pump gene can be a halorhodopsin gene.
La présente invention concerne lutilisation dune molécule dacide nucléique isolée comprenant une séquence nucléotidique codant pour un gène de canal ionique ou de pompe contrôlé par une lumière hyperpolarisante à partir dun archéon ou pour un fragment actif à la lumière dudit gène ou la séquence nucléotidique complémentaire de ladite séquence nucléotidique, pour le traitement ou lamélioration dune cécité. Le gène de canal ionique ou de pompe contrôlé par la lumière peut être un gène dhalogénorhodopsine.
Balya David
Busskamp Volker
Lagali Pamela Sarita
Roska Botond
Fetherstonhaugh & Co.
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Insti Tute For Biomedical
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