Novel thiazolidinedione derivatives as antidiabetic agents

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61K 31/505 (2006.01) A61P 31/10 (2006.01) C07D 239/00 (2006.01) C07D 473/34 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2391913

The invention relates to compounds of general formula (I), to their possible pharmaceutically acceptable salts and tautomeric forms. The invention also relates to a method for obtaining said compounds and to their utilization as antidiabetic and hypolipidemic agents, by themselves or combined with other antidiabetic agents such as sulfonylureas or biguanides, as well as to their utilization in the treatment of complications associated with insulin resistance such as hypertension, hyperuricemia or other cardiovascular, metabolic and endocrine disorders or other disorders associated with diabetes.

La présente invention concerne des composés représentés par la formule générale (I), leurs éventuels sels acceptables d'un point de vue pharmaceutiques et formes tautomères. La présente invention concerne également un procédé de préparation et d'utilisation desdits composés comme antidiabétiques et hypolipémiants, seuls ou en combinaison avec d'autres agents antidiabétiques comme les sulfonylurées ou les biguanides, ainsi que dans le traitement des complications associées à la résistance à l'insuline, telles que l'hypertension, l'hyperuricémie ou d'autres troubles cardio-vasculaires, métaboliques, endocriniens, ou d'autres associés au diabète.

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