C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61K 31/519 (2006.01)
Patent
CA 2580656
The present invention relates to novel compounds, in particular novel thieno- pyridine and thieno-pyrimidine derivatives according to Formula (I), wherein all radicals are defined in the application. The compounds according to the invention are positive allosteric modulators of metabotropic receptors - subt ype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
La présente invention concerne de nouveaux composés, notamment, de nouveaux dérivés de thiéno-pyridine et de thiéno-pyrimidine de formule (I), dans laquelle tous les radicaux sont tels que définis dans l'application. Les composés de cette invention constituent des modulateurs allostériques positifs de sous-type 2 des récepteurs métabotropiques ("mGluR2") qui sont utilisés dans le traitement ou la prévention de troubles neurologiques et psychiatriques liés à un dysfonctionnement du glutamate et à des maladies, dans lesquelles est impliqué le sous-type mGluR2 des récepteurs métabotropiques. Notamment, de telles maladies constituent des troubles du système nerveux central sélectionnés parmi le groupe comprenant l'anxiété, la schizophrénie, la migraine, la dépression et l'épilepsie. Ladite invention a aussi pour objet des compositions pharmaceutiques et des procédés de préparation de ces composés et compositions, ainsi que leur utilisation dans la prévention et le traitement des maladies, dans lesquelles mGluR2 est impliqué.
Cid-Nunez Jose Maria
Duvey Guillaume Albert Jacques
Imogai Hassan Julien
Le Poul Emmanuel Christian
Lutjens Robert Johannes
Addex Pharma Sa
Addex Pharmaceuticals S.a.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Janssen Pharmaceutica N.v.
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