C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/22 (2006.01) A61K 31/38 (2006.01) C07D 333/12 (2006.01) C07D 333/38 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 495/04 (2006.01) C07F 7/08 (2006.01) C07F 9/6553 (2006.01)
Patent
CA 2484822
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
Cette invention se rapporte à un procédé servant à traiter les symptômes d'un trouble aigu ou chronique médié par la voie classique de la cascade du complément, ce procédé consistant à administrer à un mammifère nécessitant un tel traitement une quantité thérapeutiquement efficace d'un composé de formule (I), ou d'un solvate, hydrate ou sel pharmaceutiquement acceptable de ce composé; formule dans laquelle R?1¿, R?2¿, R?3¿, R?4¿ et R?7¿ sont définis dans les pièces descriptives de la demande, Z représente SO ou SO¿2? et Ar représente un groupe aromatique ou hétéroaromatique tel que défini dans lesdites pièces descriptives.
Ali Farah
Ballentine Shelley K.
Chen Jinsheng
Cummings Maxwell D.
Gushue Joan
3-Dimensional Pharmaceuticals Inc.
Johnson & Johnson Pharmaceutical Research & Development L.l.c.
Mbm Intellectual Property Law Llp
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